A number of weapons seem to bug after reload, meaning you end up in a bugged state unable to fire, move properly, open the pipboy etc, and it takes awhile for that effect to wear off (or general mashing of the keyboard). Only seems to affect long load weapons like the Cowboy Repeater, 357 Revolver, Trail Carbine, Lever Shotgun etc. It makes using those weapons an exercise in frustration.
Also another issue is that when using the 357 Revolver in VATS it rarely hits anything (even with a 95% chance to hit).
Edit: Ignore the sound issue (found an independant fix).