I don't think any game has had the option to be left handed. The option would just complicate things. I'm left-handed, and I'm over it.
I can't think of many at all. The issue is that you'd need to recreate combat animations for the lefties, reflecting them from right hand might work, I don't know, but it would be a far bit of work getting them aligned and scripted.
Only games I do know of that let you play left or right are the odd FPS, where there's less animations.