I think you can sprint longer and sneak a little better in clothing, but I'm not certain. And I'm not sure if those aforementioned weightless perks negate the sprinting penalty, and that's assuming it really is there, since I'm going by the UESP wiki which is not entirely accurate right now.
If you're not wearing any armor, you can get an Alteration perk which massively improves the power of the protection spells.
If you use only a main-hand weapon and nothing in the off-hand, you can block and bash with the weapon just like a two-hander. Problem is, the game has a bug that makes it impossible to empty a spell from a hand slot without equipping then un-equipping a weapon to that slot, and I would recommend using some Alteration and Illusion in the off-hand every once in a while.
If you really want a swashbuckling type character though, I think you should use either two swords, or a sword and a dagger. It would be even better if you occasionally swapped the off-hand dagger with an Alteration/Illusion spell like I mentioned, especially to activate a protection spell.
The dagger in the off-hand would not only fit the Swashbuckler thing best I think, but I believe it would make your sneak attacks stronger. And one of the benefits of clothing I think would be the slightly better sneaking.