I'm not sure what the deal is - a driver conflict? I uninstalled the previous drivers - the BF3 Beta driver is the only one installed.
I have an Intel i7-930 @ 2,80ghz, 6GB DDR3 ram and a GTX480. The game runs great at a solid 60fps with everything maxed out.

When i got the game on release it first crashed at the beginning (where you get out the vault and the first enemy jumps you) - my entire computer crashed and rebooted.
I thought this might've been an overheating issue - the CPU/Memory usage/temp looked normal though - still, lots of dust, cleaned the case, game worked fine the second time around and i played it for a solid three hours.
I figured that might've been it.

Patch came out, booted up the game again. After another hour i reached the boss-fight in the Dead City (that huge ogre thing/rocket-launcher battle)
In the middle of the fight - poof - my computer crashed, rebooting it - again.
This is obviously very annoying and I'm really not sure what's causing it (I also don't have this problem with any other 'demanding' game by the way)

Should i wait for new drivers? Do more people have this issue?
Anyone have an idea?

is your computer crashing back to desktop or blue screen of death crash???

Not even a BSOD. The power just falls out and the computer reboots right after.
It's like a short-circuit or emergency shut-off - but RAGE is the only game/program i have this issue with.

I have the same issue. Computer just shuts down likeit lost power. It happened twice in single player last week and in multiplayer it happens everytime, it doesnt last no more than 5min. Also, It happened to me yesterday while surfing the web. I dunno...

Q6600 @ 3.0
6gig ram
gtx260 216
ozc gamerxtream 700watt

I got a BSOD playing RAGE before. Right after I shot an enemy in the head I got a USBPORT.sys bsod. That's the very first time I've ever seen that bsod, and I've seen A LOT of bsods.

Can you please tell me what Power Supply you use and how many W it has...

It could be CPU overheating, use speedfan to keep an eye on the temperatures.

http://www.almico.com/speedfan.php

It's 700watt - should be enough.

And i'm monitoring my CPU temps - they're all in the normal zone. It's not a power/overheating issue.
As i said, RAGE is the only game crashing my computer, i can play Metro 2033 maxed out for example, which is a way more demanding game.

I can confirm I had this a lot too.

I have also had a lot of BSOD in NTFS.sys

I have also had lots of programs crash after I close Rage including Windows Plug and Play service.

This sounds almost like what happened to me that caused me to run a memory test as well as change around my drivers due to the driver constanly crashing. It drove me nuts cuz i thought for sure my pc had a hardware dieing when i stoped playing rage it stopped happening. Im almost wondering if the game has a memory leak because this certinly sounds like one.

It must be a memory leak in the video drivers caused by the game. Only drivers can cause the OS to crash.

I have similar crashes and haven given up playing until we get some kind of patch or updated driver release...