For some reason my computer isn't picking up discs when I put them in my disc drive, I just tried to re-install Vampire the Masquerade: Bloodlines and it wasn't reading the disc or even registering that the disc is there. Though it might be a problem with the disc, took it out cleaned it and tested with several others and it's still not showing. I haven't installed any new programs recently, any chance this is a virus?

Your computer has been hacked. The only solution is amputation and a CPU transplant.

In reality: Can you see your disc drive in my computer when there's no disc in there? Is it listed under device manager?

http://support.microsoft.com/kb/314060