Hmm that's an interesting idea, I never picked up on the Fallout series so I didn't know about this issue.
If the symptoms match, there's a possibility. I think most people agree that when you first start playing, the framerate drops don't kick in after long play sessions. Long play sessions only cause framerate drops if your total playtime and/or save file are already exorbitant.
If this is incorrect, feel free to correct me. That's my understanding, anyway. But if people are getting severe stutters in their first or second long play sessions, who knows? Cell buffers could be a problem, whether they're the only cause or not.