Since many of the bonuses are flat, many don't scale well with high damage weapons, like a plasma infused guass rifle (+10 energy damage I think). But doubly result in amazing combinations such as the explosive minigun I got from some raider. That modifier give it +15 explosive damage and minor AOE per shot, and with the miniguns base damage being 8, that effectively tripled it's damage out put. Let me tell you, you don't even need the bloody mess perk to turn your enemies into viscera with that weapon.