Please also note my earlier caveat, which applies to all quests, radiant or otherwise:
Important caveat: at the moment, any quest that is present in the plugin and running in the game will be restarted when you hot-load the plugin.
So, if you are in the middle of a quest, you should not expect to be able to maintain the current quest state across a hot-load of a plug-in that includes changes to that quest.
The safest approach (in the sense of "least likely to fail or give you weird results") is to make a save prior to even starting the quest that you're developing. After you hot-load your plugin, also reload that save.
And again, depending on how you've changed your quest, that still might not work right.
The general rule when using hot-loading is:
safety not guaranteed.