Try the Catalyst 10.10e hotfix with the latest Crossfire Game Profile
http://support.amd.com/us/kbarticles/Pages/gpu88-catalyst-10-10e-hotfix.aspx - 10.10e
http://sites.amd.com/us/game/downloads/Pages/crossfirex-app-profiles.aspx - Crossfire Game Profile 10.11
10.10e offers a few tweaks and options not yet found in the official 10.11 Catalyst.
When Catalyst 10.12 is released, the features of 10.10e will be present.
I use this combo with no issues in FalloutNV, or anything else for that matter.
I have a 5970 Crossfire setup.