I do hope for one thing that the house can't be damaged or destroyed in anyway....
I would rather not comeback from a gathering more Dwemer artifacts for study, dealing with the political elite of Solitude or a mass killing spree to find that some dragon's burnt my house down.
There's been no real structural destruction thus far, and I'm not sure if the game engine is capable of it. So I'll put my bets on the houses not being able to be destroyed.