sounds like it is sound (:D). if its only happening when a character is speaking, then it more than likely is sound-card based. try updating drivers, if tried, try a diff card if you can
Running Win 7 x64
Video Card: GTX260M, I am having the same problem. FPS drops to 15 or less when I engage dialog with someone. As well I notice the frame rate is all over the place however I can deal with FPS issues bouncing around but not going from 50 FPS to 15 every time I speak with a character in game. I tried installing new drivers, installing older drivers. Re-imaged my machine with a recovery disk, reinstalling everything (including the video drivers) still the same problem in the game. I updated the video drivers once again, same problem.
I've tried everything, including uninstalling sounds drivers, resintalling and updating. Still issues, frustrating!