Any idea why my game crashes instantly after start up then since my latest update when it was working fine with 1.5?
You have updated SKSE and Script Dragon right? Latest SKSE version is http://skse.silverlock.org/ and Script Dragon was just updated to work with http://www.gamesas.com/topic/1355668-rel-script-dragon-topic-6/page__view__findpost__p__20963675.
If you are up-to-date and still crash, backup then delete your Skyrim and SkyrimPrefs ini's in your skyrim saves directory, and let the skyrim launcher generate fresh ones, then load the game up without changing settings.
Edit: Quoted wrong post.