1. The marker in Dead Space was built and placed on Aegis VII to see what would happen. The necromorph outbreak was the result. They somehow suppressed it, buried the marker, and put the whole planet as "off limits" to everyone. Granted, Unitologists may or may not have had something to do with CEC illegally starting a mining operation on Aegis VII, but in any case, we know how it ends. Necromorphs get on an shuttle and crash onto the Ishimura...spreading the "plague." Marker is destroyed. Necromorphs contained/destroyed with it.
2. Earthgov gets Issac Clarke and uses the codes in his head from exposure to the marker to build another one. The goal...study and understand it for whatever secrets they can gain. Okay, they tried that before Dead Space and Aegis VII showed what could go wrong. It's safe to presume that in Dead Space 2, it wasn't until the Ishimura was brought to Titan station that the "goo" on board was reanimated into Necromorphs by the newly built maker...starting the outbreak there.
So. How stupid are these people? They know what the marker can produce and that it has always ended in disaster. They know that it would be best to do any testing in an isolated place they could scuttle with nukes with the press of a button rather than risk contamination of a major population center. The Isumura should have been flown into a star, not salvaged (like they'd get all of that goo off the ship). You would think knowing the threat the marker poses by itself and the danger Unitologists pose because of their fanatical obsession with the marker(s), Earthgov would be a lot smarter in how they go about studying them.