Doesn't exist in the CK, as far as I know (I never heard of it, anyway).
Some NPCs won't execute packages - maybe - when the Cell is not loaded (PC not in it ... though that's not always true, tends to be a few cells loaded at any one time) because they are "encounter NPCs" (and/or levelled actors).
Often these do not spawn (do not exist) until the PC enters the cell (or triggers them in another way) ... and unless the Template Actor has those packages (I think, if I remember that bit correctly).
So it might be that?
Often Aliases are used, because of this; are you using Aliases to hold your packages, and then filling the aliases with actors when needed?
Are these NPCs you created? Or are they vanilla NPCs? Do you know if they are "encounter" or "levelled" actors?