I don't like the sneak-attack idea, since a DB assassin could kill you with an Iron Dagger, but the pickpocket idea would be neat. And if you joined the Thieves Guild, they stopped (since it's against their code)
For some time I've thought that it only seems right for NPCs to be able to sneak attack and pick pocket your character. Also maybe use some of the illusion spells. It only seems fair, and realistic.
I've seen an enemy NPC sneak when we were fighting, though it may have just been a glitch in the system. Pickpocketing would be interesting but I see many people complaining. Their problem would be that they didn't notice the thief take something and soon enough the PC would be missing most of their things...