The game seems overall favoured towards 'good' players. I actually almost find it hard to be evil, first off almost everytime you kill a hostile you gain karma.
Second there's not enough 'evil' things to do and the 'evil' routes for quests all seem to be kind of "Heh I can kill people.". There isn't any reason for your character to be evil (add hated be everyone) other than because you can be. Remember Fallout 3 blowing up Megaton gave you a HUGE caps boost early in the game, it made being evil a real temptation. That's what's missing from the karma system in this game.
My current character has very good karma, but I don't see her as good. I roleplay, she does help people, but only if they can pay, and only as long as a better paying oppurtunity doesn't present itself along the way. I play a character that's selfish and does anything to get her way, I still have good karma even if I steal whenever I need to, kill people and trick people into risking their necks so I don't have to.
Karma is a completely arbitrary way to define a character.