This is part of what my Encumbrance Module does (which is part of my Realism Tweaks). I haven't ported this module over to my NV Tweaks yet, as I'm currently working on my Hard-Core Module (while completing a Major update to my FO3 Tweaks). It should be done in a few weeks.
My NV Realism Tweaks currently only uses Fatigue damage as part of my optional Weapon Effects (along with a Fatigue display).