I am running 2 x 5850s in eyefinity with 3 x 23 inch monitors and in crossfire. I had nothing working till Joelll told me to try this. All I did was uninstall all your catalyst stuff. Then install 11.10 catalyst suite. in ccc turn off veertical refresh ( set slider all way to left ) restart and run the game. I am running smooth as silk and so far no issues.