I have over 200 hours into this game, clean cache, no problems with other DLC's. Just started the Dragonborn DLC and game is freezing every 5 min. Sometimes I'm walking, sometimes in the middle of a battle. What can I do? I've disabled all the autosaves, which didn't help at all.

Does it freeze with a new character? If yes, try to reinstall the DLC. If it does not, then your save might be wonky.

I've gone back to previous saves, didn't work. I haven't started a new character because I'm so far in.

Would it matter whether I'm playing from the hard drive or disc?