Originally I thought this was isolated to just the cowboy repeater however after getting a lever action shotgun off a fiend I believe it maybe lever action weapons. Current bug/glitch apparently is when the weapon is reloaded and the reload animation is completed. For some reason the game doesn't believe the weapon is finished reloading and makes it wait anywhere from 3 to 10 seconds more. Had several issues with the Cowboy repeater weapon and actually refuse to use it now instead using it for caps. As mentioned I found the same issue with the lever action shotgun which fires the 20 gauge shells.
Problem: Either dry reloading or reloading with rounds still in the chamber does not matter. It appears to be isolated solely to the weapon reload animation and the game not understanding that the reload animation has finished. Tried several things to cancel the reload process, but it seems ignore the commands continuing to reload. This probably causes me to not be able to access my pipboy, switch to a new weapon, or open doors.