I have windows 7 64bit. My hard drive is a Samsung spinpoint F3, from the reviews it is supposed to be a pretty fast Hard drive.
I know nothing about that HD, sorry. I hope some of this helps.
El Z is spot on. Use the FNV tweak guide and the Windows 7 64 tweak guide by the same author. I recommend you take a day to go through them, doing the Win 7 64 guide first. They did great for me.
I'm one of the lucky few that have not had any real problems. I installed FNV about a week ago, installation went smooth and is running like a champ.
This was before going through the tweak guides. Afterwards my fps went up a bit. I've left FNV running for 2 days without a crash.
Ran a lvl 3 character from Primm to New Vegas without a save, just parked my char in the middle of the Strip and let the vanity cam do its thing.
Incredibly, it is even running stable in a window.
Before I update to today's patch, I'm going to continue reading feedback on it and probably wait until Hearts is released.
Fwiw, I've always had crash issues with FO and Oblivion on this rig.
But I modded the H*ll out of Oblivion (without FMods) and I haven't uninstalled Windows Live or SecuROM yet.
Maybe someday I will get back to them...
i7 920 2.67Ghz
8GB DDR3
Windows 7 64
Samsung HD642JJ (Standard SATA drive)
2048x1152
(replaced) Nvidia GTS 220 1GB (Handled FONV on High settings and tweaks via game guide. FNV auto-chose med settings)
Nvidia GTX 550 Ti 1GB (Plays smoothly on ultra settings. I'll retweak those game settings at some point. FNV auto-chose High settings).