The title pretty much says it all. At the conclusion of "Diplomatic Immunity," as I leave the Reeking Cave and begin loading the Skyrim overworld, the load stutters and then my box dies. I have loaded saves from several hours previous and the glitch is consistent and game-ending. Uninstalling the game and clearing my HD cache have not helped.
I have a lot of tolerance for the sort of bugs you usually find in games of this size - weird quest flags, missing textures or whatever - but this is of a much more serious order and has pretty much killed my enthusiasm for the game.