I have STR=1 and END=1 and play on Survival with no real problems (aside from the usual BGS glitches here and there, as well as FO4 using rather cheap one-shot skills such as Super Mutant Suiciders). I also do not use drugs aside from Rad-X, Radway, and Stimpacks as I see them as medical aids rather than street chems.
Bloodbugs Hatchlings at the start on the way to Concord... dead with one Molotov Cocktail. Flying insects are very vulnerable to fire despite their damage dealing abilities otherwise. Same is true for stuff like Mirelurks (they don't like fire and take a lot of damage from it).
I do not find enemies to be very bullet spongy in FO4 on Survival. I do not find that I need to focus entirely on combat- and damage-enhancing perks until I have established myself on an equal footing with the enemies (unlike prior games where this type of approach was almost required for higher difficulties due to the enormous bullet sponge effect). In my view, BGS balanced Survival very well, much better than their prior games.
Companions can also be helpful at lower levels due to drawing melee. Codsworth is as lethal to flying insects as Molotov Cocktails. Dogmeat is far better versus Molerats or Raiders and not very helpful with flying insects. This makes sense and helps role playing.
It also helps role playing that the enemies are actually dangerous rather than something you automatically take out with a couple of 10mm rounds.
You've just awakened from a 200 year cryogenic sleep. You are NOT in good shape at all and won't be for some time. The encounters and game world should be quite lethal at low levels. It makes sense that you would gradually toughen up and build up more stamina, health, etc as you explore the initial surroundings. Intelligent characters would stay near the starting area(s) for a long time in order to properly equip themselves, train themselves, learn about this new world they are in, and (hopefully) establish some alliances with individuals and/or groups who can help them. Intelligent characters would NOT run off chasing after whoever kidnapped Shaun as that would be a sure way to get killed and not be able to do anything at all about what happened. Of course, if you're like me, you are role playing a different type of character than the base character provided by BGS anyway. BGS games aren't about quests, anyway.
Assuming you are actually role playing in this world, you'd want to do some rebuilding. You will gain quite a bit of XP just from basic rebuilding (not completing anything, mind you, because you can't due to the extreme materials/resources limitations). I'm not talking about "power leveling" but simply role playing a reasonably intelligent character.
One thing, though... BGS games have glitches, bugs, etc and FO4, in particular, includes some utterly silly cheap kills against the player. Normally, Dead is Dead players are allowed reloads if death occurs due to game errors or something similar. Use your own judgment rather than blindly adhering to always "death=perma-kill". In some instances, death being permanent kill makes no sense because the game is actually designed for players to be cheaply punished from time to time but able to reload with no problem. The design can be flawed in some cases for a solely DiD approach.
BTW, the reason to take Medic or do things other than using Stimpacks (or Radaway) is role playing, the entire point of the game. It is not up to developers to force players to play only one way by limiting in-game supplies. It is up to developers to include in-game elements that allow for the widest variety of role playing possibilities they can.