I know the Dark Brotherhood will be the fourth guild one can join besides Companions, Mages and Thieves. What I would like to do with my character is to hunt down those sons of sneaking dogs and wipe them from the face of Skyrim. I also found some info already about how the Dark Brotherhood can be found and what quests one has to do to probably finally be able to join them. Is something like attacking and killing NPCs of guilds usually possible in Elder Scrolls games? Maybe also after having joined that guild even only to infiltrate them?
Would be great if I could go down that road with my 'Nord warrior with a vengeance'. Taking on a whole guild and make them your sworn enemies sounds like a good time to fill your days before starting the dragonborn destiny route.

Maybe the Spoilers forum is not the right place for such a question. But I thought I play it safe in case the only available information would be from some leaked footage. If this thread belongs to the other Skyrim forum please feel free to move it, moderators. Thanks.