Alright, to start I was hanging about in Markath and found, randomly, that I could not drop Alto Wine anymore (only the one with the wicker basket on it). I did not think this was a big deal because I don't drink the alcohol but then it happened again with the giant's toe. Now I am worried it might spread to other items. Anyone else experiencing this issue?

I can give more detail about my copy if that would help but so far that is the only inventory issue I had have.

To add a bit more:
I can not trade, sell, use, or drop these items. They act as if they aren't there but still weight me down. I experienced this just after doing the quest where a man challenges you to a drinking game and you end up in Markath which drug poor Wilhelm into all there quests. I think I had not completed the Deadric quest (House of Horrors) at the time of this happening. If this help, which I hope it does, please inform me how to either a.) fix it or b.) help fix it.

Thanks!

P.S:
The set of a.) and b.) are to disable emoticons and allow for symmetry (a.k.a why A has it as well).

You are on a particular quest. You had a drinking contest and woke up in a strange temple all the way across the world? If this sounds familiar, read the repair note in your book section and look at your quests

I have same issue, you can read about it up here: http://www.gamesas.com/index.php?/topic/1266332-how-to-get-rid-of-stuck-quest-items/page__pid__19219766
I recommend you to go to Whiterun to the inn, get on with a drinking contest with Sam that will "teleport" you to Markath, then do not bribe or intimadate/persuade the priestess but "clean the room" and return her toe and other items.

So what I am thinking is that I might be able to fix this "glitch" by completing "Night to Remember"?