Everything I've tried so far - All starting outside of Riverwood immediately after getting the Alduin's Wall quest:
Disable mods through Nexus Mod manager, cleansave, clear local files in Steam, delete Skyrim folder, reinstall from disc using method outlined in these forums, load from launcher instead of SKSE, disable hires DLC - no
*Tried the last 20 saves, the final one being before I downloaded any mods - no (took a while because I had to get all the way to the Alduin's wall quest each save)
*TLL: No - disable LOD, reload cleansave, FTT to Old Hroldan, proceed toward Karthspire cell, CTD
*COC: No - coc karthspirecamp gets me to the camp, but the moment I get to where I discover Karthspire proper, CTD
*COC KarthspireCamp + TLL: no
*coc karthspirereboubtexterior: no
*coc karthspireredoubtstart (inside of the cave) and walk outside to continue the quest: no
*above+ setstage + port esbern and delphine in: no, they don't talk about the quest
*above - setstage: no, they freeze, CTD
*any of these + TAI (just a wild guess): no
*Got the Creation Kit. dikeed around in it for a bit to try and see if I could mod the Karthspire experience so it would work. No dice.
*Was at ATI 12.3 - downgrade to 12.1 ATI drivers, upgrade to 21.4 - nope, neither
So this is a complete gamebreaker. Any help would be appreciated.