after the patch, the game will freeze solid and require holding the power button on the PS3 to power off, when I turn it back on it gives me a big warning about not shut down properly, need to checkdisk the drive, etc.
Seems to do this randomly, not always after an area load or after a quest marker but usually after one or the other.

having some other typical glitches -
bookshelves are broken
mannequins are usually invisible

but also a couple of other problems,
marriage is hit or miss depending who, some won't go to the house and will only go back to their house no matter where you say to live
a big one is the thieves guild quest line is broken - I was on the last quest (return the skeleton key) and it glitched back to "get the translation for the journal" so I did that again, now when I try to do the skeleton key - I get to the pit, Nocturnal does her thing then says talk to Keriah and disappears. Problem is Keriah just does the "hmmm?" response and wont start a dialogue. So no way out, stuck in the hole, etc.
The other guy, Sobjorn or whoever, with the guild is still walking around in the cistern and just does the "Sorry lad, too busy to talk" thing and wont go into a dialogue menu either,
Can't buy the house in Windhelm, cant get the murder solving quest to start. Ulfric says buy a house and be a Thane, his steward says "Theres a house but its not quite ready due to some unfortunate event"

Also my menus are almost unusable!!
most of the time I'll have to bring up the character menu 9 or 10 times to be able to actually select something, but the skills menu is the worst. Trying to actually go up or down one of the skill trees is virtually impossible.

I love the game!
But I'm getting pretty frustrated with it now, especially with the lockups potentially threatening the integrity of other data on the hard drive!

BUMP and yeah me too. Just happened now actually so it's given me time to make a post. It's the second time and like you said, it gives a scary warning on how it was shut down improperly and then it rebuilds itself.

I'm not sure it this is because of the 1.2 patch of the firmware 4.00 or a combination of both.

Also i found a backwards dragon, still lags, weapons take forever to take out sometimes and again bookshelves Armour racks and mannequins are all broken.

I guess my companions quest line is trashed too because the "retrieve the helm of windhelm" quest was still open when I got the "wipe out the silver hand" quest.
So I have companions stuck doing their after the attack thing and varkas just wants to talk history.
It also took the "get the item to enchant from athis" quest with it since he's stuck lying on the floor.

So now I can't finish the thieves guild OR the companions quest lines.