So, I'm doing the Unlikely Valentine quest and Mama Murphy is talking about the glowing sea. Is there any way to get the dialogue option for Skinny Malone and Nick now... or am I just SOL?

What drug is she asking for? you might have already asked her about it?

With that said you don't "Need" any of the tips to do the missions although that one and the "courser" one can come in handy depending on your level.

Can I ask a Mama Murphy question as well, if there is an expert on her? I waited till after the Main Quest to rescue them from Concord and for the hell of it did her junkie errands, anywho she was talking about a room and a key under the bed or something or another. I have no clue what she was going on about. Is that familiar to anyone?

Mama Murphy's "predictions" are far too general to ever be wrong. Typical carnival fortune teller.

It's for the quest where you have to break into Kellogg's house. If you get her prediction, a secret key that isn't available otherwise becomes visible under the stairs so you can break into Kellogg's house.

Ah I see. Well he's been dead for a year in my game by that point, haha. Thanks.