Everyone ends up ridiculously rich in Skyrim.

I guess you can spend some on weapons and armor - but if you do smithing you probably make them yourself, and ebony weapons are standard draugr boss loot once you reach a higher level (not even that high). You can buy houses, training, filled soulgems for enchanting... If you get Hearthfire spend them on building houses.
I usually simply stop looting after a certain point. I take unique/unusual things, gold, potions, lockpicks, soulgems and gems (can't leave the shiny shiny things). That's it.