Please actually describe the issue. Just saying it doesn't work says absolutely nothing. Also, please ensure you're using the latest version of the game. The latest version is 1.7.x.
Uninstall all remaining mods and other third-party add-ons. Do not simply disable them. All their associated files need to be gone from the game's directories. Then start a new game. If things work, then you'll likely get better help here: http://www.gamesas.com/forum/183-skyrim-mods/