Few things im excited for after reading many peoples different opinions:
-Non Scaling enemies (makes for a much more intense gaming experince as you have to think plan and strategize your engagements with the Creatures and factions of the wasteland.
-Returning back to the west coast for. (great for guys like me who have played fallout since it came out back in the 90's)
-Death Claws are kick ass again! (nuff said)
-Faction system (makes the games replay value all the better as each play through can result in different experinces with said factions.)
-Modding system for weapons (Customization=fun)
-LOOT! (In a game with non scaling enemies having to go past that cave or building that is surrounded by enemies that you know are going to pwn you makes the feeling of finally going in there and getting the gear or loot all the better!)
any way just a few things im pysched about. Yes i know there are glitches but ive played oblivion and morrowind and FO3 and im used to it as are many other people.