I figured Two-Handed (Claymore) / Alchemy / Light Armor are a must. The Dragon Shouts would substitute the Signs as I am not really interested in a lot of magic. But apart from those 3 skills, I am left wondering what else would be necessary... maybe Block, but so many of the block perks involve shield, I don't know how that would work with a two-handed... maybe stealth, but then no damage multiplier for two-handed...
Also, not having played Oblivion much, how does poisons fare with Two-handed? Most games I have played poisons and fast weapons go hand-in-hand and they loose their efficacy with slower weapons, how does that usually work in the Elder Scrolls?
Thank you.