There's a current problem being highly reported over the PS3 version in that when the saved data files reaches a certain size (usually around 5-6 mbs), the game starts stuttering and slowing down to the point of unplayability. Keep that in mind and know that it doesn't take all too long (at most maybe 25-30 hours) before that size is reached. I'm hoping it's not true as I'm approaching that size now, but sadly, I think it may very well be.
I've also heard thats happening. I've never had that problem with a Bethesda game but only cause when i bought them, patches were available. So i'm gonna wait until some patches come out and hopefully they resolve the problem.