I play Overgrowth. It's very interesting. This game should have locational damage, but it seems that it may be a problem. Suppose you are nearing the end of the mission, but your leg is hurt. You can't leave the area quickly and are shot, leaving you to reattempt the whole mission again. Now this may be a penalty for getting shot in the leg in the first place, but there needs to be something to alleviate this kind of scenario.
There could be checkpoints, or simply a save system. I agree, this system would be very cool, but might lead to some headaches, but that might make the game more realistic and awesome! Eh, I don't know. I'm sure Arkane will do whatever is best. I just hope that they don't do the red circle blood system. And cool, another person who plays Overgrowth!