However, it seems they changed Desmond's appearance so much. He looks [censored]. Subject 16 looks like the biggest [censored] bag known to man.
That's because he's stuck inside the Animus, it's more like a subconscious projection of him (notice how he doesn't even have his scar)
Spoiler He will wake up near the end of Rev and look like the Desmond we all know and love again).
As for 16, I was biased towards him since he was first mentioned in AC2, I just don't like him and I think he looks freaky in Rev and he annoyed me with his so-called 'crazy' behaviour, but.... near the end he did something that really surprised me and made me think, "Oh, he's really a pretty decent guy!"
I don't know where you are in the game right now, but like you I've been an AC fan since the very beginning and like you I had trouble getting into Rev to the point where I haven't touched the 360 version after 2 hours of playing on release day because I hated how it played, and waited for the PC version hoping it would be better. And even then I didn't get into it until I was about... 1/3rd in.
All I can say is, try to get through it, even if you only end up playing it once, for the story because it does get really good. It's the beginning that lacks.
Especially if you liked Alta?r (you may need to have a box of tissues near you if you're like me). If you're still early in the game there's a good chance you'll still get into it. I couldn't put it down after a while. Even though the game ends with another massive cliffhanger for the next game, it also answers a lot of questions left behind in Brohood.
The one thing that made it difficult to get into for me was the stupid notoriety system (because in Rev buying shops raises it as well for some stupid reason) and that quickly leads to the stupid Tower Defending mini game. If you happen to play on PC and don't mind a little cheating for the greater good, get a trainer with a Reset Notoriety function. Instant improvement!