http://www.rockethub.com/projects/7509-projet-crevette-save-children-from-disease - A project to eliminate a debilitating parasite from west African rivers by re-introducing a native species of prawn that died out following a dam construction. It will not only help eradicate this disease-causing parasite, but it will also provide a source of food and income for the local people. (NOTE: Unlike Kickstarter, the project doesn't have to be fully backed for them to get the money, as soon as you donate, that's it).
http://www.kickstarter.com/projects/celsiusgs/drifter-a-space-trading-game - First, http://celsiusgs.com/ks/Drifter800px.jpg. Gorgeous. If you enjoyed games like Elite and Privateer, you'll definitely want to check this one out. A 2.5D game with some very pretty space graphics, and music by the composer of games such Super Meat Boy, Binding of Isaac, and Cave Story 3D. They've just added stretch goals for a professionally-designed UI, a Linux version, hijackable ships, and atmospheric flight.
http://www.kickstarter.com/projects/379113968/spate: A 2.5D platformer with a murder mystery set in a noir, steampunk world created by one of the artists of Tim Burton's Alice in Wonderland and Cloudy with a Chance of Meatballs. Not backing this one myself because it's not really my sort of game, but its world design is something I'd like to see more of.