There's mod for that.

Any mod that claims to reduce likeliness of CTDs usually don't. They may make performance better in some cases... I used an underwear mod once that made the loincloth a speedo just because it said it would make the game run better. It didn't...
All I got to say is, see what mods you have installed. I can't use some for one reason or another, especially Garret's Retreat... Sadly. That mod makes my game crash. Not sure why.