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Website: http://skse.silverlock.org/
Latest version (1.5.10, supporting runtime 1.7.7 released 24 July 2012): http://skse.silverlock.org/beta/skse_1_05_10.7z
The Skyrim Script Extender, or SKSE for short, is a modder's resource that expands the scripting capabilities of Skyrim. It does so without modifying the executable files on disk, so there are no permanent side effects. For details of the Papyrus extensions, read skse_papyrus_docs.txt. For Actionscript extensions, read skse_docs.txt.
Gopher has made a http://www.youtube.com/watch?v=xTGnQIiNVqA if you are having trouble with the instructions in the readme file.