I think flesh spells are unnecessary once you have good armor. As for two-handed vs. sword&board, it's a matter of preference - the former lets you deal more damage, the latter gives you more effective blocking, some protection from arrows/spells and bash.
My character started off as a dual-wielding warrior, but recently I've also been trying my hand at sword&board. When facing a tougher enemy, like a dwarven centurion, I still switch to 2h - a few hits and the enemy's down.
I recommend that at the beginning of the game, you try out a bit of both styles and see what suits you more. It's possible that you'll find both skills useful depending on the type of enemy/type of location. In this case, nothing is preventing you from investing in both perk trees.