So far sneak attacks with a well repaired Varmint Rifle seems to put these things down. Early game at least seems to favor high sneak snipers with all the open areas that have long sight lines.
Go ahead, try that on a Giant Radscorpion... tell us how it goes
I thought radscorpions were tough up until I ran into some Cardozas. Now, radscorpions look like bloatflies compared to them. My god I hate frickin bees so much.