Pretty simple. When things don't go to plan, do you reload, or see what you can do to salvage the situation? I find that usually I try my best to roll with it, and sometimes that works out, but other times I end up with a knife through my neck. But nevertheless, there is a great satisfaction in getting spotted by a guard and escaping successfully. That satisfaction isn't there if the moment something goes wrong, you reload. Of course, if you're doing a Clean Hands/Ghost playthrough, it's okay.

Well I'm on my 2nd playthrough and I'm going for no kills and Ghost, so when things don't go according to plan - as in, if I'm spotted, I usually reload it. But first I kill all the people who are alerted just because its fun!

My first playthrough if I missed a jump or got caught, I'd do my best to escape and I'd roll with it

Depends on what happened. If it is a glitch (like Choke-out failing) I reroll otherwise I roll with it.

This is my first play through. Future plays I'm sure I will reload if going for an achievement. First time, I'm just going with it and playing as if it was me and how I would do things.

Reload. I'm going for ghost, nonlethal, and very hard. Mistakes will be made.