I've found a fully replicatable bug when entering the Outrigger Territory for the spare parts mission.

The game just freezes and wont let you progress any further, making you have to kill the game in control panel.

Any hints how to get past this? Should I cancel the mission and re pick it up? Am I just stuck in hell of this happening?

Or is it a graphics issue and I need to tone down the settings?

Update to this - it only seems to be happening on the ATV, if I run in on foot nothing craashes/freezes.

BTW Machine Specs are:

Alienware M17X Laptop
I5 Processor
ATI 5800 Graphics Card
Windows 7 64BIT
8GB RAM

Exactly same problem here. Game runs fine until I start moving and crashes within seconds.

AMD Athlon II X2 260
ATI HD5770 Graphics Card with Catalyst 11.6
4GB Ram
Win 7 64Bit

Seems to just randomly happen - just had it in the Garage section after getting the pistons whilst I was on foot. Why oh why cant they make this game work properly!!

I had the same problem, at the same position/quest. Every time i tried to go to the Outrigger Territory, the game froze. It didnt matter if i went with the ATV or if i ran.
I actually loaded a save game before taking on the quest with the spare parts. With this i was able to take the quest and drive to the Outrigger Territory if nothing had ever happend.