I played through with one character, so I am familiar with the quests when they appear. The first weird one I got was J'Zargo's Flame cloak quest. I picked them up, and later on, when I decided to try them, i didn't have the scrolls anymore. I though I might have stored them... but quest items usually can't be dropped etc. Hmmm....
Then, I got the Red Eagle quest.... did it. A while later.... picked it up again..... the place did not had the boss again though.... The J'Zargo Scrolls I was able to get from him again.... I wonder how many quests will be respawning! And how many will be "stuck" as a result of completing them once!
I tried to keep information to a minimum to avoid spoiler spanking! But this is really general discussion topic I feel.