They wake up to a different world.
Their family is gone.
Their friends are gone.
Even that [censored] from Vault Tek who thought it was necessary to bother you before you had a chance to enjoy your first cup of coffee of the day is gone (Ok, not everything turned out for the worst).
All I am saying is let the poor protagonist have a week or two for the shock to wear off before you send him/her out on the prowl.

But I hope you get what I mean that by the time the PC does move on it will already be weeks/months lore wise.
I'll hide beneath my rock of loneliness until Bioware releases Mass Effect 
