So I'm looking at installing a bunch of mods for the first time. Some of them from the steam workshop and some from the nexus. For the most part a lot of the mods don't overlap, but some alter the loot enemies drop. Monster mod alters actual enemies and I have a bunch of new item mods like Immersive Armor that add new items for enemies to drop. Will these work together?

Also does anyone know if Guide for the Perfect Blacksmith will interfere with new craft-able item mods?

Skyrim Monster Mod doesn't alter enemies per se - it adds new enemies, or new variations of enemies based on vanilla ones - and gives them a chance of appearing in spawn lists. Immersive Amors and Skrim Monster Mod worked fine together for me when I did a test, alongside many other mods. If different mods affect the same lists, you'd need to use Wrye Bash to create a Bashed Patch to merge the lists.