My Sanguine Rose has never worked.
The weapon will use a charge as expected, but nothing is summoned.
I attempted re-loading a previous save and acquiring a new rose and still the same problem.
If I attempt to cast the staff straight up in the air or at a target too far away, the cast will fail and will not use any charge...
Casting the staff on the ground, or on an NPC, however successfully uses a charge, but has no other effect.
Some other annoying things:
My mercenary companion (Jenassa) will never wield a bow she is given. She does use a bow... but the bow she uses does not even appear in her inventory.
The items placed in the house in Whiterun will be all over the floor upon return to the house.... and the item placing mechanic is horrible.
When dual-casting a one-handed bound weapon... it will always appear in the left hand. I use my melee weapon in my right hand.
I've got over 20 pounds of quest items in my inventory, many of which have no quest yet.
Shards of Mehrune's razor... some drum, a dagger, several unusual gems, a few dragon claws, curious silver mould, etc. (picking up an unremovable quest item should add a misc quest...or make them weigh nothing like in oblivion)
Quest items that are weapons cannot be removed from your inventory.... but they CAN be placed on a weapon plaque?
I killed a blood dragon and the body never deteriorated/I never got a dragon soul... I reloaded the save and the problem still persisted.... the dragon's corpse remains un-deteriorated (and soul remains unabsorbed) at the location where the dragon was killed.

Update: Same thing just happened to me with an Elder Dragon, and some time before that a Frost Dragon. This is somewhat rare.... but it does happen enough for it to be a nuisance.... I have absorbed plenty of other dragon souls since the glitched ones.
anyway... I love the game otherwise... just getting a bit frustrated here and there.