Lockpick: Locking - You can actually lock doors!
Speech: Assisted Suicide - While in combat, you are able to talk human enemies into killing themselves.
I really like this lockpicking idea, it would be great if you were inside and needed to get away from an enemy and could lock them out. Smarter enemies like robots or BoS would be able to pick the lock quickly but enemies like Super Mutants and Fiends would be stuck to find a new way to reach you. this would have been a much better perk for Fallout 3 trying to get away from Super Mutant Overlords.
I was actually thinking about a locking perk earlier today but I was thinking of locking containers so that the Factions safehouse residents and Lucky 38 companions would stop taking consumables.
Your Speech perk made me think of another potential speech perk
Speech - 90, "Holy shi- what is that over there?!" convinces the enemy to turn and look away leaving you free to run away or shoot them in the back, will fail on a few smarter enemies.
Survival - 90, Recipe outputs are doubled or create your own campfire/hotplate!
Medicine - 90 Dr. Frankenstein, Revive a fallen companion
Barter 90 - Wallet Inspector, opens up a dialogue option where you can convince anyone to let you see their belongings leaving you free to steal a few things, don't stick around them long though, after a minute they'll realize they've been swindled by a smoothe talking jacka**.
or
Gun inspector - convince a non-hostile NPC to allow you to "inspect" their gun allowing you to attack them when they are unarmed