Your game is NOT supported, supported patches: 1.1.21.0 (31oct11)..................1.5.26.0
(the "......." is all patches in between)
I've tried defragging the cache files, verifying the game integrity, and uninstalling and re installing.
This error happened after I bought Dawnguard and I haven't been able to play since then... (bought it probably 2 days after it came out on the PC)