Hey, I've been playing Skyrim for a few days now (steam shows 23h which is kinda scary) and so far I've been loving the game apart from the menus which gives me some serious headache at times.
First of all the mouse cursor is really picky on where you're pointing it when you're stashing items in a container or simply just looting stuff, especially when you try to click on the "misc" tab you can't always just simply click on it... there's a specific spot where you have to click (like next to the text instead of on top of it) for it to work.
Also the conversation screen on PC is really just completely broken. At times it works fine while most of the time your mouse cursor is again trying its best to make everything as hard as possible for you, at times it does not properly highlight the dialogue options even though you're waving the mouse cursor on top of them but it simply gets stuck in one of the options, you try using WASD or the arrow keys and those don't help so you will try to exit the conversation which introduces yet another problem.

The TAB button to exit a conversation... it doesn't work half the time, it really doesn't. No matter how many times I press that button during the end of some conversations it just doesn't want to work. Also if I have that bug which I explained earlier about the game just getting stuck in one of the dialogue options, you try to click on the exit conversation button which is on the lower right corner of the screen and it just chooses the dialogue option that it was stuck on and leaves the conversation afterwards.

But the biggest problem I've had is that there has been times when I've got stuck in a conversation. This happened during one of the early companion quests, I had only 2 dialogue options with the NPC and the exit conversation button which should be located at the lower right of the screen is simply gone. I try pressing TAB and nothing happens so I'm stuck in the conversation and there's no way to exit. I had this problem just a moment ago again in Dawnstar with a NPC called Madena and each time I spoke to her I got stuck in the conversation with her since the exit button disappeared and TAB, as always does nothing... And when this happens you can't simply load since saving and loading functions are disabled during conversations, you have to exit to main menu and then load the game.

Please Bethesda, do something about these problem as they're driving me nuts.