No. You can never make anyone else a thrall. This is something I think bethesda could have gone further with. Yes, mindslaving random npcs could make things easy mode but if they implemented it right it could work. You could only do it once a week or every few weeks, and you could turn that person into a companion or a servant for your house or castle. Maybe he could carry your weapons? Shine your boots? Backrub perhaps? You could also just let them go about their lives, but you could command the to fight for you if the guards try ajd attack (but you could enthral them too). You could also have them for feeding. If you really wanted to, you could enthrall entire populations, but it would take in-game months to accomplish. Sometimes, if you're THAT determined to make the game easy, I think they should let you haha
This is a great idea, it would really add to the fun of being a super powerful vampire.
Also, there is already a way to turn up and down the difficulty, so who cares how easy Thralls make the game?